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Medical Conditions Associated with IIH

Most associated conditions with IIH are from disease processes or medications that cause increased pressure within the brain

Idiopathic intracranial hypertension (IIH) is a rare neurological disorder described by the modified Dandy criteria  where pressure in the brain is elevated causing symptoms of headache, vision changes, pulsatile tinnitus, sixth nerve palsy, and a constellation of other signs and symptoms. This increased pressure can lead to permanent damage to the brain and eyesight if left untreated. IIH contains the word ‘idiopathic’ because there is no specific cause to explain this process. As researchers continue to investigate the pathophysiology of IIH, many questions can be answered. Epidemiological studies have helped show that there is a correlation between certain diseases and IIH. This article will review the well-documented diseases shown to be prevalent in patients with IIH but is not limited to this list.

Most associated conditions with IIH are from disease processes or medications that cause increased pressure within the brain, or cause symptoms similar to IIH like headaches, nausea, and dizziness.

Known conditions associated with IIH:

Medications that have been linked to causing or worsening IIH:

  • Tetracycline
  • Cyclosporine
  • Lithium
  • Nalidixic acid
  • Nitrofurantoin
  • Oral contraceptives (OCP’s)
  • Levonorgestrel
  • Danaxol
  • Tamoxifen
  • Vitamin A excess or deficiency₃

Endocrine abnormalities associated with IIH:

  • Corticosteroid withdrawal
  • Anabolic steroids
  • Excessive growth hormone
  • Thyroid disease

Specific conditions associated with IIH and men:

  • Testosterone deficiency
  • Sleep apnea₃

It is important to note that since IIH is seen in women in their fertile years, conditions like pregnancy, PCOS, and menstrual irregularities are commonly seen in this cohort and in women in this age group without IIH. In other words, regardless of one’s medical condition, most women between the ages of 16-50 will experience one or more of the above conditions. Though IIH is known to commonly associated with obese females in their fertile years, it has been diagnosed in men, prepubescent children, and non-obese females.₃

This article is not intended to have one with IIH discontinue treatment of any of the above medications but to be an advocate for yourself and address it with your medical team.

The hope is with more investigation into the pathophysiology of IIH, to remove the word ‘idiopathic’, and focus on exploring ways to cure this debilitating disease.

  1. Markey K, Uldall M, Botfield H, et al. Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. Journal of pain research. April 19, 2016;9:223–232. https://doi.org/10.2147/JPR.S80824
  2. Glueck, C. J., Aregawi, D., Goldenberg, N., Golnik, K. C., Sieve, L., & Wang, P. (2005). Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia. Journal of Laboratory and Clinical Medicine, 145(2), 72–82. doi:10.1016/j.lab.2004.09.011
  3. Thurtell M, Bruce B, Newman N, et al. An Update on Idiopathic Intracranial Hypertension. Rev Neurol Dis. 2010;7(0):e56-e68. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674489/)
  4. Albuquerque F, Dashti S, Hu Y. Intracranial Venous Sinus Stenting for Benign Intracranial hypertension: Clinical Indications, Technique, and Preliminary Results. World Neurosurgery. May-June 2011;75(5-6):648-652. https://www.sciencedirect.com/science/article/abs/pii/S1878875010008570

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